The final report will be published here in German language after completion.

Short report:

The aim of the research project is a piezoelectric sensor that allows an immediate, highly sensitive quantification of MRSA in situ (piezoelectric MRSA detection). The detection principle is based on the coupling of photo-induced acoustic waves into a piezoelectric material oscillating in resonance after binding of living MRSA cells and marking of bound MRSA cells by antibody-functionalized acoustic probes.

Irradiation with pulsed monochromatic light induces periodic temperature changes of the acoustic probes, which lead to the formation of acoustic waves (photoinduced acoustic waves). When the photo-induced acoustic waves reach the piezoelectric material, they are coupled into it and interfere with the electrically induced acoustic wave present there. The amplitude of the resulting acoustic wave depends directly on the number of labelled MRSA cells bound to the piezoelectric material.

By means of the piezoelectric MRSA detection, cleaning and hygiene service providers can directly prove the success of cleaning/disinfection measures carried out to the hygiene commission in hospitals. If necessary, corrective measures can be initiated immediately. Critical points (frequent skin/hand contact) can be determined by the hygiene commission and regularly examined by cleaning and hygiene service providers for MRSA contamination.

With the data obtained, hygiene professionals can optimize hygiene plans and improve strategies to avoid contamination, which are essential for the prevention of nosocomial MRSA cases and the containment of MRSA spread.